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Mi, 13.01.2021 22:00
pta20210113035
Business news for the stock market
Medigene AG: Medigene expands patent protection of its technologies in key markets, the USA and EuropePlanegg/Martinsried (pta035/13.01.2021/22:00) - Medigene AG (Medigene, FSE: MDG1, Prime Standard), a clinical stage immuno-oncology company focusing on the development of T cell immunotherapies, was granted patents around certain technologies in significant territories including both the USA and Europe. Patent applications in further jurisdictions are pending.
TCR library (US10,858,760)
The two TCR protein chains, alpha and beta, together determine the specificity of the TCR. The patent covers a library comprising 92 TCR constructs (including all 45 different TCR alpha chains and all 47 different TCR beta chains) that are needed as starting materials for recombinant expression of any TCR of interest. The constructs also include design elements for flexible exchange of any other TCR region and adaptor sequences that enable reconstructed TCRs to be shuttled into recipient T cells by different means. This library enables rapid high-throughput reconstruction of large numbers of candidate TCRs specific for selected antigens and provides tools to reconstitute TCRs specific for mutations on a patient-individualized basis. Efficient reconstitution of many TCRs in parallel enables those sequences with the best functionality to be rapidly identified and selected for TCR-T cellular therapeutics.
CrossTAg-1 (EP3394247A1)
This technology allows cross-presentation of antigens on both class I and II Major Histocompatibility Complex (MHC) molecules (also called "Human Leukocyte Antigens", HLA, in humans) thereby stimulating both killer T cells and helper T cells, respectively. These major T cell subsets play key roles in immune responses, including those against cancer. The CrossTAg-1 technology directs short peptides from an antigen to be effectively processed by cellular pathways for both class I and class II HLA presentation. Thus, Medigene also believes that using the CrossTAg technology could potentially improve T cell responses to mRNA-based vaccines.
CrossTAg-2 (US10,882,891)
Medigene Immunotherapies GmbH and the biomedical research center Helmholtz Zentrum München are co-applicants for the mentioned CrossTAg patents which fall under the main license agreement in place with Helmholtz Zentrum München. Prof. Dolores J. Schendel, CEO/CSO of Medigene: "Medigene's growing patent estate reflects the wide applicability of its ongoing innovation and scientific excellence across the field of therapeutic T cells. Building the patent estate covering these technologies in key commercial markets is of core importance to protecting the value of our investments in innovation. We believe our technologies could provide important benefits to deal with the constant challenges facing clinical medicine in solid tumors and infectious diseases." --- end of press release ---
About Medigene
For more information, please visit www.medigene.com
About Medigene's TCR-Ts
Medigene is conducting a first Phase I/II clinical trial of its TCR-T candidate MDG1011 in the blood cancer indications AML and MDS as well as a second Phase I clinical trial of MDG1021 in patients suffering from relapsed or persistent blood cancer after allogeneic (non-self) hematopoietic stem cell transplantation (allo-HSCT). In addition, Medigene is establishing a pipeline of TCRs and has collaborations with bluebird bio, Inc. and Cytovant Sciences HK Ltd. addressing solid tumor indications.
About Medigene's DC vaccines
Dendritic cells (DC) can take up antigens, process them and present peptides on their surface in a form that can induce antigen-specific T cells to mature and proliferate. In this way, T cells recognize and eliminate tumor cells which bear the same antigen peptide on their surface. Dendritic cells can also induce natural killer cells (NK cells) to attack tumor cells. The scientific team of Medigene has developed new, fast and efficient methods for generating autologous (patient-specific) mature dendritic cells, which have the relevant characteristics to generate very strong T cell and NK cell immune responses. The dendritic cells can be loaded with various tumor antigens to treat different forms of cancer. Since an immune response builds up over the total time of administration of the DC vaccine, this form of therapy is particularly designed for patients who suffer from a tumor disease which has been reduced to such an extent by chemotherapy that the prevention of the recurrence of the tumor disease is the main goal. This press release contains forward-looking statements representing the opinion of Medigene as of the date of this release. The actual results achieved by Medigene may differ significantly from the forward-looking statements made herein. Medigene is not bound to update any of these forward-looking statements. Medigene® is a registered trademark of Medigene AG. This trademark may be owned or licensed in select locations only.
Medigene
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In case you no longer wish to receive any information about Medigene, please inform us by e-mail (investor@medigene.com). We will then delete your address from our distribution list. (Ende)
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Walter Oblin sieht Post auf Wachstumskurs 18.04.2023 ETARGET
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